Mounjaro works by activating areas in the brain that sense fullness and regulate food intake. This helps reduce appetite while enhancing satiety, meaning you feel content with less food. Over time, it can help reshape eating patterns by supporting a more natural balance between hunger and satisfaction. The science behind hunger control Appetite control depends on communication between the gut and the brain. After eating, the body releases two hormones — GLP-1 (glucagon-like p

Mounjaro mimics the effects of GIP and GLP-1 hormones, which influence brain regions that control hunger and satiety. It slows stomach emptying, helping you feel full for longer after eating smaller portions. By reducing cravings and promoting fullness, it makes it easier to stick to balanced, mindful eating habits. How the GIP and GLP-1 hormones signal fullness Both GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) are gut hormones releas

Mounjaro is most effective when combined with a balanced diet and regular movement, such as walking, swimming, or cycling. The medication helps regulate appetite and blood sugar, which can make lifestyle changes easier to sustain. Working with a healthcare professional or dietitian can help tailor these habits for long-term success. Why lifestyle still matters NICE and NHS guidance emphasise that Mounjaro should always be used alongside lifestyle modification. The medicine he

For kidney or liver issues, the dose ladder is usually the same, but clinicians monitor more closely. No routine dose adjustment is needed for mild-to-moderate impairment, yet dehydration from nausea or vomiting can stress the kidneys, so hydration and slower titration matter. In severe impairment or if labs are changing, prescribers may pause or hold at a lower step and review more frequently. Always flag any new swelling, dramatic fatigue, very dark urine, or reduced urine

Yes. Many people prefer to inject after a cool-down so the site is relaxed and less tender. Avoid injecting into a muscle you’ve just trained hard, and rehydrate before and after your session. If vigorous workouts trigger nausea on injection day, choose a different time or move the workout to the next day. Why exercise timing matters Wegovy (semaglutide) can be injected before or after activity, but comfort improves when the body is calm. Because injections go into the fatty

There are no strict activity bans. Most people tolerate light-to-moderate exercise well; if you’re doing very intense sessions, consider injecting afterwards or on a rest day while you’re settling in. Avoid massaging the injection site, and skip heavy core work immediately after if it makes the area sore. Hydrate well — especially during dose increases — because dehydration can worsen nausea or dizziness. Why activity matters with GLP-1 medicines Wegovy (semaglutide) is alway

Standard UK instructions start at 0.25 mg once weekly and step up gradually to improve comfort and reduce tummy side effects. Starting at 0.5 mg is not the routine plan and tends to increase nausea for first-time GLP-1 users. If you’ve previously tolerated a GLP-1, your prescriber will still weigh the pros and cons before deviating from the usual start. Why titration matters Wegovy contains semaglutide, a GLP-1 receptor agonist that acts on appetite control centres in the bra

Trials such as STEP-1 and SELECT showed Wegovy not only reduced weight but also improved blood pressure, cholesterol, and markers of heart health. Other medicines, like Saxenda, also improve some metabolic measures but to a smaller extent, and drugs like Orlistat mainly affect fat absorption rather than broad cardiometabolic outcomes. Why metabolic health matters Weight management is not just about the number on the scales. Many of the health risks linked to excess weight — i

Neither Wegovy nor Saxenda requires strict dietary rules. Both are prescribed alongside a reduced-calorie diet and increased physical...

In STEP trials, people using Wegovy started to see weight changes within the first 4–8 weeks, with maximum effects building over about a year. Ozempic, studied mainly for diabetes, also showed early improvements in blood sugar and weight within weeks, but average weight loss was smaller because of its lower doses. Early signs of progress One of the most common questions people ask is how soon results can be seen. In clinical trials of Wegovy (semaglutide 2.4 mg), participants

There are no strict dietary restrictions, but simple tweaks help you feel better on treatment. Smaller portions, slower eating, and higher-protein meals reduce nausea and keep you fuller for longer. Early on, many people do better with lighter foods and by limiting very rich, spicy, or greasy dishes. Hydration matters — sip water regularly, and consider a little extra salt if you’ve cut back on processed foods and feel light-headed. Alcohol is best kept moderate, especially w

Wegovy was developed by Novo Nordisk as a higher-dose formulation of the GLP-1 receptor agonist semaglutide for chronic weight management, building on earlier experience with semaglutide for type 2 diabetes. Its evidence base comes from large, international STEP trials focused on weight and related health markers, with additional research exploring cardiovascular and kidney outcomes in selected groups. UK adoption is guided by national appraisals and commissioning policies; S

Wegovy does not “boost metabolism” in the thermogenic sense; its primary action is appetite regulation and reduced intake. As weight decreases, resting energy expenditure typically falls a little — that’s a normal adaptation seen with any weight loss. The meaningful advantage here is reduced hunger and cravings, which makes long-term behaviour change more realistic. Improvements in metabolic risk markers are observed in many users, but they stem from weight reduction and bett

The medicine is intended to sit alongside a reduced-calorie diet and regular movement, not replace them. People usually find it easier to meet protein targets, shrink portions, and cut between-meal snacking when appetite is quieter. Light-to-moderate activity protects muscle while weight comes down, and small daily habits (steps, resistance bands at home, shorter eating windows that suit you) compound gains without feeling punitive. UK services will tailor this mix and adjust

The first few weeks focus on getting used to weekly injections and allowing your body to adapt at a low dose. Common early effects...

Appetite suppression with semaglutide comes from activating GLP-1 receptors in brain regions that govern hunger and satisfaction,...

"Only 8 out of 42 health boards are offering Mounjaro... so what's the hold up?" You've guessed it - Mounjaro is in the news again due to the latest controversy of the King-Kong weight loss jab being touted as 'available' on the NHS.... so what exactly is going on? Why are thousands of patients still waiting for a treatment that could transform their lives? Mounjaro was meant to be rolled out across the NHS in England from 23 June for those with the highest clinical need unde

Taking the step to use Wegovy for weight loss is exciting, and you’re probably eager to see the best possible results. Diet and nutrition play a pivotal role in enhancing Wegovy’s effectiveness, and knowing what to eat, how to plan your meals, and getting expert advice can make all the difference. In this blog, we'll delve into some common dietary queries, offer meal planning tips, and share suggestions from nutritionists to help you on your weight loss journey. Ready to get

Are you ready to embark on a journey toward a healthier, more balanced lifestyle with Wegovy? You're in the right place! A balanced diet is crucial when you're using Wegovy for weight loss. In this blog, we'll explore nutritional guidelines you need to follow, dive into some fantastic sample meal plans, and understand the dietary restrictions and recommendations to keep in mind. Imagine the possibilities of feeling your best and achieving your fitness goals with a well-rounde

In the pursuit of better health, understanding your unique metabolic profile is paramount. Personalized metabolic assessments offer...