If you remember within 5 days, take the missed dose as soon as you can and then resume your normal weekly schedule. If more than 5 days have passed, skip that dose and take the next one on your usual day. Don’t double up to “catch up” — that raises the chance of side effects without helping results. Why missed doses happen No treatment plan is perfect, and it is common to forget a dose of medicine occasionally. Wegovy is taken once a week, which makes it easier to fit into li

It doesn’t matter — Wegovy can be taken with or without food. Some people feel more comfortable injecting after a light meal or a protein-rich snack, especially early in treatment when mild nausea is more likely. Choose the routine that keeps you consistent and comfortable. Why food timing doesn’t matter Wegovy is not swallowed like a tablet but injected under the skin, where the medicine is absorbed gradually over a week. This means its effectiveness is not affected by what

Yes. You can change to a new weekly day as long as at least 3 full days have passed since your last injection. Once you switch, keep using the new day each week. If you’re unsure about the timing, ask your clinic to help you plan the change. Why flexibility exists Wegovy is designed as a once-weekly injection, and the dosing rules were created with real life in mind. Few people manage a routine that never changes. Work patterns, holidays, travel, or family events can all inte

Any time of day works — morning or evening — because the weekly dose is designed to be flexible. Pick a time you can stick to, keep it the same each week, and set a reminder so doses aren’t missed. If your routine changes (shift work, travel), you can move the time as long as your weekly schedule stays consistent. A flexible schedule Wegovy is designed as a once-weekly injection, and its long half-life means the exact time of day does not affect how well it works. Whether you

Yes, Wegovy and metformin are often used together in people with type 2 diabetes, and no special dose adjustment is typically required. They work differently: Wegovy (a GLP-1 receptor agonist) reduces appetite, slows stomach emptying, and boosts insulin release, while metformin mainly reduces glucose production in the liver and improves insulin sensitivity. Why combination treatment is common Many people living with type 2 diabetes require more than one medicine to manage blo

In major STEP trials, Wegovy led to about 15% weight loss over 68 weeks. Contrave (called Mysimba in the UK) generally achieves around 6–9% across pivotal studies. This means semaglutide tends to provide greater weight reduction than naltrexone/bupropion combinations. Two very different medicines Although both Wegovy and Contrave are used for weight management, they belong to very different drug families and work in different ways. Wegovy contains semaglutide, a GLP-1 recepto

Wegovy contains semaglutide at a higher dose and is licensed for weight management, while Trulicity (dulaglutide) is prescribed for type 2 diabetes. Weight changes with dulaglutide are usually modest compared with the significant reductions seen in trials of semaglutide for obesity. Different active ingredients and purposes The first key difference is that Wegovy and Trulicity contain different GLP-1 receptor agonists. Wegovy delivers semaglutide at doses up to 2.4 mg weekly,

Use once weekly, same day each week, with or without food, alongside a reduced-calorie eating plan and regular activity. Keep hydrated,...

Standard UK instructions start at 0.25 mg once weekly and step up gradually to improve comfort and reduce tummy side effects. Starting at 0.5 mg is not the routine plan and tends to increase nausea for first-time GLP-1 users. If you’ve previously tolerated a GLP-1, your prescriber will still weigh the pros and cons before deviating from the usual start. Why titration matters Wegovy contains semaglutide, a GLP-1 receptor agonist that acts on appetite control centres in the bra

You can change your weekly injection day if needed, as long as there are at least 3 days (72 hours) between two doses. After switching, keep to the new weekly day going forward. For missed doses, the rule is different: if you are within 5 days, take it as soon as you remember; if it has been more than 5 days, skip it and take the next dose on your usual day. Why flexibility is built in Wegovy is prescribed as a once-weekly injection. The idea is to give people a medicine that

Yes — official tutorial videos exist and are helpful, but they don’t replace the patient leaflet or nurse/pharmacist teaching. Ask your clinic to point you to their preferred video and walk you through the device steps. If anything in the video differs from your pen’s instructions, follow your pen’s leaflet. Why videos can help Learning an injection technique is easier when you see it done. A clear video shows hand position, pen angle, and the pace at which the button is pres

Check your dose strength, attach a new needle, and follow the step-by-step device guide (including the brief “flow check” where shown)....

Recommended sites are the abdomen, thigh, or upper arm. Rotate sites each week to reduce local irritation, and avoid areas that are tender, bruised, scarred, or inflamed. If a spot stings or looks red after, switch to a different area next time and mention it at your review. NHS training stresses that choosing the right location improves comfort and consistency over the long term. Why injection site matters Wegovy is given subcutaneously, meaning the medicine needs to sit in

Wegovy is injected under the skin (subcutaneously) once a week, not into a vein or muscle. Wash or sanitise your hands, choose a clean,...

Wegovy has been tested in large clinical trials and shown to deliver sustained, clinically meaningful weight loss. Over-the-counter supplements rarely have robust evidence and typically produce little to no lasting effect, so the gap in proven effectiveness is significant. What makes Wegovy different Wegovy contains semaglutide, a GLP-1 receptor agonist that has been through rigorous clinical trials involving thousands of participants worldwide. The STEP programme of studies

Yes, trial evidence shows that Wegovy works best when combined with healthy eating and physical activity, leading to average weight losses of around 15%. Saxenda and Trulicity also perform better when paired with lifestyle support, but semaglutide at the doses used in Wegovy generally results in greater overall reductions. Why lifestyle support matters No weight-loss medicine is intended to work on its own. NICE guidance makes clear that drugs such as Wegovy, Saxenda, and Tru

Many people on Wegovy report fewer food cravings and better control over eating, which can reduce stress around meals. Other drugs like Mysimba may also affect mood and cravings, but semaglutide’s impact on appetite tends to have the strongest indirect psychological benefit. Why psychological effects matter Weight management is never only about the body. Emotional wellbeing, self-confidence, and the stress of managing food choices all play a big role in how people experience

Clinical trials included adults up to their mid-70s, and weight loss benefits were seen across age groups. There’s limited evidence directly comparing older versus younger adults, but no major differences in effectiveness have been noted, though older people may be more sensitive to side effects. Who was included in the trials The large clinical trials of semaglutide, such as the STEP programme, included adults with overweight or obesity up to about 75 years old. This means w

Wegovy is made as a biologic medicine, meaning it uses recombinant technology to produce semaglutide, a protein-based drug. Mysimba and Orlistat, by contrast, are small-molecule tablets made by chemical synthesis. These differences influence regulation and supply but not day-to-day use for patients. What makes Wegovy a biologic Wegovy (semaglutide) belongs to a group of medicines known as biologics. These are typically large, complex molecules produced in living cells using r

Both contain semaglutide and improve blood sugar by enhancing insulin release and reducing glucagon. Ozempic is specifically licensed for diabetes at lower doses, while Wegovy provides the same benefits at higher doses alongside more pronounced weight reduction. How semaglutide works on blood sugar Semaglutide, the active ingredient in both Wegovy and Ozempic, belongs to the GLP-1 receptor agonist family. It lowers blood sugar by stimulating insulin release when glucose level