Many people on Wegovy report fewer food cravings and better control over eating, which can reduce stress around meals. Other drugs like Mysimba may also affect mood and cravings, but semaglutide’s impact on appetite tends to have the strongest indirect psychological benefit. Why psychological effects matter Weight management is never only about the body. Emotional wellbeing, self-confidence, and the stress of managing food choices all play a big role in how people experience

Clinical trials included adults up to their mid-70s, and weight loss benefits were seen across age groups. There’s limited evidence directly comparing older versus younger adults, but no major differences in effectiveness have been noted, though older people may be more sensitive to side effects. Who was included in the trials The large clinical trials of semaglutide, such as the STEP programme, included adults with overweight or obesity up to about 75 years old. This means w

Both contain semaglutide and improve blood sugar by enhancing insulin release and reducing glucagon. Ozempic is specifically licensed for diabetes at lower doses, while Wegovy provides the same benefits at higher doses alongside more pronounced weight reduction. How semaglutide works on blood sugar Semaglutide, the active ingredient in both Wegovy and Ozempic, belongs to the GLP-1 receptor agonist family. It lowers blood sugar by stimulating insulin release when glucose level

Both Wegovy (semaglutide 2.4 mg) and Trulicity (dulaglutide) improve blood sugar, but semaglutide generally produces greater reductions in HbA1c and body weight. NICE recommends semaglutide more widely for people needing weight-focused management. Two GLP-1 medicines, one key difference Wegovy and Trulicity both belong to the GLP-1 receptor agonist family of medicines. They mimic the hormone GLP-1, which reduces appetite, slows digestion, and stimulates insulin release when b

The most common side effects with Wegovy are gastrointestinal, such as nausea and diarrhoea, and these often lessen over time. Other medicines have different risks: Orlistat can cause oily stools, Mysimba may raise blood pressure, and phentermine (not used in the UK) carries cardiovascular risks. Understanding risk in context All weight-loss medicines come with benefits and risks. Doctors weigh these carefully before prescribing, taking into account a person’s health conditio

The SELECT trial showed semaglutide 2.4 mg (Wegovy) reduced the risk of major heart problems in people with overweight or obesity and cardiovascular disease. Orlistat, while useful for modest weight loss, has not shown the same scale of cardiovascular benefits in large outcome studies. Two very different medicines Wegovy and Orlistat are both prescribed for weight management, but they work in completely different ways. Wegovy (semaglutide) is a GLP-1 receptor agonist that red

Wegovy works directly on appetite signals in the brain, helping people feel full sooner and think less about food. Other medicines act...

Wegovy has shown sustained weight loss of around 15% at 68 weeks, and many participants maintained benefits at two years. Qsymia (not...

Survey and trial follow-ups suggest people report higher satisfaction with Wegovy than older GLP-1 drugs, mainly because of greater...

Since both contain semaglutide, their side-effect profiles are similar — most commonly nausea, vomiting, and diarrhoea. Wegovy uses a...

In major STEP trials, Wegovy led to about 15% weight loss over 68 weeks. Contrave (called Mysimba in the UK) generally achieves around 6–9% across pivotal studies. This means semaglutide tends to provide greater weight reduction than naltrexone/bupropion combinations. Two very different approaches Although both Wegovy and Contrave are prescribed for weight management, they work in completely different ways. Wegovy contains semaglutide, a GLP-1 receptor agonist that reduces ap

In a head-to-head trial published in The New England Journal of Medicine , people taking Wegovy lost on average about 15.8% of their body weight over 68 weeks compared with 6.4% for those on Saxenda (liraglutide). This makes Wegovy the more effective of the two for weight loss in most cases. Two GLP-1 medicines, one key difference Both Wegovy and Saxenda belong to the same class of medicines, known as GLP-1 receptor agonists. They work by mimicking a natural hormone that redu

Wegovy contains semaglutide at a higher dose and is licensed for weight management, while Trulicity (dulaglutide) is prescribed for type 2 diabetes. Weight changes with dulaglutide are usually modest compared with the significant reductions seen in trials of semaglutide for obesity. Two GLP-1 medicines, two purposes Both Wegovy and Trulicity belong to the same broad group of medicines known as GLP-1 receptor agonists. They mimic a natural hormone in the body that helps reduce

They’re not the same product: both contain semaglutide, but Wegovy is the weight-management brand (higher dose) and Ozempic is the type-2-diabetes brand (lower dose ranges). Indications, dosing schedules, and pens differ, so switching should be guided by a prescriber. Same ingredient, different goals It’s true that both Wegovy and Ozempic are based on semaglutide, a GLP-1 receptor agonist that helps regulate appetite, digestion, and blood sugar. But they were developed for di

For weight management, Wegovy (semaglutide 2.4 mg weekly) is the licensed option and generally achieves greater weight loss than the...

Choosing between Wegovy and Mounjaro comes down to what you’re aiming for (weight, blood sugar, side-effect profile) and what’s available to you. Many people see strong results with both; tirzepatide can yield greater reductions for some, while semaglutide has a longer real-world track record. Why these two drugs stand out Wegovy and Mounjaro are often compared because they’re part of the same family of treatments known as incretin-based medicines. Both act on hormones that h

Wegovy contains semaglutide, a GLP-1 receptor agonist used at higher weekly doses for weight management. It helps reduce appetite and supports lower energy intake alongside everyday habits like balanced eating and movement. What semaglutide actually is Semaglutide is a medicine that mimics GLP-1 (glucagon-like peptide-1), a natural hormone in the body. GLP-1 plays a key role in appetite and metabolism: it slows the emptying of the stomach, enhances the release of insulin when

After stopping, many people regain some weight over time because appetite signals gradually return toward baseline. How much and how quickly varies, but the pattern is common across all weight-management approaches. Planning ahead helps: keep protein intake consistent, maintain activity that preserves strength, and agree a follow-up plan with your team (for example, a slower taper, maintenance strategies, or alternative support). If you stop because goals have been met, expec

The first few weeks focus on getting used to weekly injections and allowing your body to adapt at a low dose. Common early effects...

Some people notice appetite changes within the first few weeks, but the medicine is introduced gradually to improve tolerability, so its...