Support starts with your prescribing service: nurse-led education, injection training, and scheduled reviews. Pharmacists can help with device checks, storage questions, and travel letters. Many NHS weight-management programmes offer dietitian input and behaviour support; local availability differs by nation and Integrated Care Board / health board. Stick to official resources for technique and safety; if something online conflicts with your pen’s leaflet or clinic advice, fo

In major STEP trials, Wegovy led to about 15% weight loss over 68 weeks. Contrave (called Mysimba in the UK) generally achieves around 6–9% across pivotal studies. This means semaglutide tends to provide greater weight reduction than naltrexone/bupropion combinations. Two very different medicines Although both Wegovy and Contrave are used for weight management, they belong to very different drug families and work in different ways. Wegovy contains semaglutide, a GLP-1 recepto

Wegovy contains semaglutide at a higher dose and is licensed for weight management, while Trulicity (dulaglutide) is prescribed for type 2 diabetes. Weight changes with dulaglutide are usually modest compared with the significant reductions seen in trials of semaglutide for obesity. Different active ingredients and purposes The first key difference is that Wegovy and Trulicity contain different GLP-1 receptor agonists. Wegovy delivers semaglutide at doses up to 2.4 mg weekly,

Yes — official tutorial videos exist and are helpful, but they don’t replace the patient leaflet or nurse/pharmacist teaching. Ask your clinic to point you to their preferred video and walk you through the device steps. If anything in the video differs from your pen’s instructions, follow your pen’s leaflet. Why videos can help Learning an injection technique is easier when you see it done. A clear video shows hand position, pen angle, and the pace at which the button is pres

Check your dose strength, attach a new needle, and follow the step-by-step device guide (including the brief “flow check” where shown)....

Recommended sites are the abdomen, thigh, or upper arm. Rotate sites each week to reduce local irritation, and avoid areas that are tender, bruised, scarred, or inflamed. If a spot stings or looks red after, switch to a different area next time and mention it at your review. NHS training stresses that choosing the right location improves comfort and consistency over the long term. Why injection site matters Wegovy is given subcutaneously, meaning the medicine needs to sit in

Wegovy is injected under the skin (subcutaneously) once a week, not into a vein or muscle. Wash or sanitise your hands, choose a clean,...

Yes, trial evidence shows that Wegovy works best when combined with healthy eating and physical activity, leading to average weight losses of around 15%. Saxenda and Trulicity also perform better when paired with lifestyle support, but semaglutide at the doses used in Wegovy generally results in greater overall reductions. Why lifestyle support matters No weight-loss medicine is intended to work on its own. NICE guidance makes clear that drugs such as Wegovy, Saxenda, and Tru

Wegovy mimics the hormone GLP-1, acting on the brain to reduce appetite and slow digestion. Contrave (naltrexone/bupropion) affects brain reward and craving pathways, which can reduce emotional eating but doesn’t directly target satiety hormones. How Wegovy works Wegovy (semaglutide 2.4 mg weekly) is a GLP-1 receptor agonist. It mimics a natural gut hormone called GLP-1, which signals to the brain that you are full, slows down stomach emptying, and enhances insulin release wh

Phentermine can produce modest, short-term weight loss, but it is not licensed in the UK for obesity treatment. In contrast, semaglutide...

Many people report fewer intrusive food thoughts, less urgency around snacking, and improved control in situations that previously triggered overeating. That can ease emotional or stress-linked eating because the immediate pull of ultra-palatable foods is quieter. Wegovy isn’t a treatment for mental-health conditions, so ongoing support — sleep, stress tools, counselling if needed — remains important. If mood changes occur, tell your clinical team so they can review and suppo

Wegovy isn’t licensed in the UK to treat fatty liver or other conditions directly, but weight reduction can improve liver fat and broader...

Storage is straightforward: keep pens in the refrigerator in their original carton, and do not freeze. Protect from light and check the...

Wegovy acts directly on GLP-1 receptors; effects on ghrelin and leptin are indirect and vary between individuals. By strengthening...

Wegovy is a once-weekly subcutaneous injection given into the abdomen, thigh, or upper arm. Rotate sites each week and avoid areas that...

The duration is guided by your response, tolerability, and local commissioning policy. Services typically build in review points — for example, at six months and at later milestones — to check progress and decide on continuation. Some pathways set a maximum course length; others allow ongoing use if agreed benchmarks are met within specialist care. Your team will set expectations clearly at the start so you know how and when decisions will be made. Why duration is not the sam

Suitability depends on your health profile, but many people with common conditions like type 2 diabetes or high blood pressure can use Wegovy within specialist care. If you take insulin or medicines that can cause low blood sugar, your prescriber may adjust doses to reduce hypo risk as appetite changes. Blood-pressure tablets usually continue as normal, with routine monitoring as weight and salt intake shift. People with a history of certain rare endocrine or pancreatic issue

For long-term weight loss, sustained treatment in structured services has shown meaningful average reductions, with plateaus that are...

Some people notice appetite changes within the first few weeks, but the medicine is introduced gradually to improve tolerability, so its...

The dosage schedule is once weekly on the same day, using a step-up “titration” plan to reach a maintenance dose. A common pathway starts low (for example, 0.25 mg weekly) and increases in stages (0.5 mg → 1.0 mg → 1.7 mg) toward a usual maintenance dose of 2.4 mg weekly, with each step typically lasting several weeks. If side effects occur, clinicians can extend a step or pause before moving up; this flexibility is standard practice across UK services. People scheduled for p